In the physical sciences and engineering, measurement is the activity of obtaining and comparing physical quantities of real-world objects and events. Established standard objects and events are used as units, and the measurement results in a given number for the relationship between the item under study and the referenced unit of measurement. Measuring instruments and formal test methods are the means by which this translation is made. All measuring instruments are subject to varying degrees of instrument error and measurement uncertainty.

Physicists use a vast range of instruments to perform their measurements. These range from simple objects such as rulers and stopwatches to electron microscopes and particle accelerators. Virtual instrumentation is widely used in the development of modern measuring instruments.

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